We study the differential branching ratio and CP asymmetry for the exclusive decay B --> K*l(+)l(-) in the three Higgs doublet model with an additional global O(2) symmetry in the Higgs sector. We analyze the dilepton mass square q(2) dependency of these quantities. Further, we study the effect of a new parameter of the global symmetry in the Higgs sector on the differential branching ratio and CP asymmetry. We see that there exists an enhancement in the branching ratio and considerable CP violation for the relevant process. In addition to this, we realize that fixing the dilepton mass gives information about the sign of the Wilson coefficient C-7(eff). Therefore, the future measurements of the CP asymmetry for the B --> K*l(+)l(-) decay will give powerful information about the sign of the Wilson coefficient C-7(eff) and new physics beyond the SM.