The Zagros Orogen formed during the Cenozoic collision of Arabia with Eurasia and resulted in the closure of the Neo-Tethys Ocean. Collision was preceded by a complicated tectonic history involving Pan-African orogenesis, Late Palaeozoic rifting and the formation of Neo-Tethys, and subsequent Mesozoic convergence on the northern margin of the ocean contemporaneous with ophiolite obduction on its southern margin. The Sanandaj-Sirjan Zone (SaSZ) is a metamorphic belt within the Zagros Orogen of Gondwanan provenance. U-Pb zircon geochronology has revealed the presence of Pan-African igneous and metamorphic basement complexes, in addition to minor late Palaeozoic plutons and abundant Jurassic plutonic rocks. This study presents a LA-ICP-MS U-Pb apatite age of 440.7 +/- 3.7 Ma from a gabbroic body on the central north-eastern margin of the SaSZ (Nodoushan region). Based on petrography and geochemistry, en route fractional crystallization of ascending magma was an important process in the evolution of the intrusive rocks. Geochemical characteristics imply that the south-west Nodoushan alkaline gabbroic magma was originated from the asthenospheric mantle source, whereas the high ratios of (La/Yb)(N) and (Dy/Yb)(N) are related to the low degree of partial melting from the garnet-bearing mantle source. Enrichment pattern of Nb, Ta, and Ti and depletion of Rb, Th, and Y are similar to the OIB pattern and intraplate alkaline magmatic rocks. High epsilon(Nd)(t) values (+1.29 to +1.50), low initial Sr isotopic ratios (0.703679-0.704098), and trace element ratios (e.g., Nb/La, Ce/Pb, Ba/Nb, and Th/Nb) indicate that crustal contamination was insignificant in its petrogenesis. The petrogenesis of the Nodoushan alkaline gabbroic rocks could be related to the presence of extensional phase, upwelling and decompressional melting of asthenospheric mantle in the rift basin which was associated with the opening of the Paleo-Tethys Ocean in Late Ordovician to Silurian times.