Versatile RNA: overlooked gems of the transcriptome

ERDEM M., Cicek M., ERSON BENSAN A. E.

FEBS Journal, vol.290, no.20, pp.4843-4851, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 290 Issue: 20
  • Publication Date: 2023
  • Doi Number: 10.1111/febs.16742
  • Journal Name: FEBS Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.4843-4851
  • Keywords: 3' UTR, chimeric RNAs, G-quadruplexes, intronic polyadenylation, isomiRs, read-through transcripts, riboswitch, RNA structure, telescripting, MESSENGER-RNAS, POLYADENYLATION, CLEAVAGE, EXPRESSION, DISCOVERY, REGIONS, VARIANT, EVENTS
  • Middle East Technical University Affiliated: Yes

Abstract

The critical role of RNA, its use and targetability concerning different aspects of human health are gaining more attention because our understanding of the versatility of RNA has dramatically evolved over the last decades. We now appreciate that RNA is far more critical than a messenger molecule and possesses many complicated functions. As a multifunctional molecule with its sequence, flexible structures and enzymatic abilities, RNA is genuinely powerful. Mammalian transcriptomes consist of a dynamically regulated plethora of coding and noncoding RNA types. However, some aspects of RNA metabolism remain to be explored. In this Viewpoint, we focus on the transcriptome's unconventional and possibly overlooked aspects to emphasize the importance of RNA in mammalian systems.