Novel surface patterning approaches for tissue engineering and their effect on cell behavior

Hasirci V., Kenar H.

NANOMEDICINE, vol.1, no.1, pp.73-89, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 1 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.2217/17435889.1.1.73
  • Journal Name: NANOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.73-89
  • Keywords: biomaterials, cell adhesion, cell guidance, cell-material interaction, chemical cues, patterned surfaces, tissue engineering, SMOOTH-MUSCLE-CELL, OSTEOBLAST-LIKE CELLS, EXTRACELLULAR-MATRIX, FIBROBLAST RESPONSE, PROTEIN ADSORPTION, IN-VITRO, FABRICATION, ADHESION, DIFFERENTIATION, POLYMERS
  • Middle East Technical University Affiliated: Yes


Methods for the creation of specially designed surfaces for use in the preparation of tailor-made tissue constructs with the ultimate aim of tissue engineering are reviewed here. Fundamental aspects of cell adhesion, proliferation and differentiation and the parameters involved in these processes are discussed. A survey of recent micro- and nano-technological methods for creating physical and chemical cues on tissue engineering carriers is presented. This overview is supported with data from the literature on various applications of different cells on materials with widely differing chemistries and physical properties. Interactions between different cell types and micro- and nano-fabricated substrates are summarized.