HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1)

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ERDEM M., ÖZGÜL İ., Erson-Bensan A. E.

Atlas of Genetics and Cytogenetics in Oncology and Haematology, vol.23, no.6, pp.137-142, 2019 (Scopus) identifier


Heterogeneous nuclear ribonucleoprotein (HNRNPA1) gene maps to chromosome 12, plus strand and has 13 exons and 12 introns. There are three reported transcripts due to the alternative splicing.
HNRNPA1 is one of the most abundant and ubiquitously expressed nuclear proteins. HNRNPA1 is a member of RNA-binding protein family comprising of 20 members in humans (Dreyfuss, 1993; Pinol-Roma, Choi, Matunis, & Dreyfuss, 1988). HNRNPA1 has diverse roles in RNA splicing, telomere length maintenance, miRNA maturation and mRNA transport from nucleus to cytoplasm.