Akademik Veri Yönetim Sistemi
Course objective:
Stem cell-based technologies have revolutionized our approaches and understanding of neurobiology within the past 10 years. Recent advancements demonstrated that human pluripotent cells can be successfully differentiated into many specific and functional neural cell types in vitro. Such human culture systems offer unique platforms for i) basic research to obtain fundamental knowledge on the differentiation and function of human neural cells, ii) high-throughput drug screening assays, iii) toxicity testing using physiologically relevant cells. Additionally, clinical applications of stem cell-based therapies on neurodegenerative diseases has been on the rise with many ongoing human clinical trials.
This course aims to introduce stem cell biology and the way in which it has developed and advanced our ability to study human neural cells in health and disease, through lectures and critical readings of current research literature. Topics include neural stem cells, embryonic and induced pluripotent stem cells, and directed differentiation of these stem cells to various neural cell types. Additionally, genome engineering methods within the context of stem cell neurobiology, and 2-, and 3-D cultures will be covered. This course will also discuss the utility of stem cell-based neural models as drug screening and experimentation platforms as well as the cell based therapies on select neurodegenerative diseases, focusing on their potential and limitations for curing human disease. This course will not only expand the theoretical knowledge of potential of stem cells in neurobiology but it also aims to introduce and emphasize current experimental approaches used in the field. The course is designed to be interactive and students will be encouraged to participate in peer discussions.
Text Book:
1. Burgess R. et al., (2016). Stem Cells: Short Course – 16th edition, Wiley-Blackwell.2. Srivastava A.K. et al., (2017) Stem Cell Technologies in Neuroscience. Humana Press.
3. Slack M.W.J, (2018) The Science of Stem Cells. Wiley-Blackwell.
4. Mummery C. et al., (2014). Stem Cells: Scientific facts and Fiction. Academic Press Publishing.
5. Arrighi N. (2018) Stem Cells. ISTE Press – Elsevier
6. Stoker et al.,(2018) Parkinson’s Disease Pathogenesis and Clinical Aspects. Codon Publications
7. Edited by Lanza and Atala, (2014). Essentials of Stem Cell Biology, 3rd Edition