Akademik Veri Yönetim Sistemi
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012, Cappadocia, Türkiye, 19 - 22 Nisan 2012, ss.88-94
RNA induced gene silencing complex (RISC) has a role in many cellular processes which includes regulation of gene expression, immune response, cell differentiation and embryonic development. Dicer protein is a key regulator of these processes. Dicer1 specifically has central role in maturation of RISC substrate RNA and RISC assembly in mouse. Here the results of a microarray study that investigates the molecular level changes in dicer1 knockout mouse liver hepatocytes is re-analysed and the differentially regulated genes are hierarchically clustered based on molecular function and co-expression to construct the suggested regulation network of Dicer1 in mouse hepatocytes. © 2012 IEEE.