LABEL-FREE DETECTION OF LEUKEMIA CELLS WITH A LAB-ON-A-CHIP SYSTEM INTEGRATING DIELECTROPHORESIS AND CMOS IMAGING

Demircan Y., Orguc S., Musayev J., Ozgur E., ERDEM M., GÜNDÜZ U., ...More

18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Alaska, United States Of America, 21 - 25 June 2015, pp.1589-1592 identifier

  • Publication Type: Conference Paper / Full Text
  • City: Alaska
  • Country: United States Of America
  • Page Numbers: pp.1589-1592
  • Middle East Technical University Affiliated: Yes

Abstract

This paper presents a fully-integrated lab-on-a-chip (LOC) system for label-free detection and real-time counting of dielectrophoretically trapped multidrug resistant (MDR) K562 cells. The system integrates a parylene-based microfluidic DEP channel on top of a CMOS image sensor for the first time in the literature. The DEP channel can trap MDR K562 cells with 9 V-pp and 10 mu l/min flow rate, and the CMOS image sensor can detect the trapped cells as small as 3 mu m in diameter with a noise level of 28.3 e(-)rms.