A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives


IŞIK M., Akkoca H. U., Akhmedov I. M., TANYELİ C.

TETRAHEDRON-ASYMMETRY, cilt.27, ss.384-388, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.tetasy.2016.04.001
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.384-388
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

A new chiral sec-amine/amidine-base hybrid catalyst, 2-aminoDMAP/prolinamide, is reported, which is able to catalyze conjugate addition of 4-hydroxycoumarin and various benzylideneacetones, a reaction that directly gives anticoagulant Warfarin and its analogues, with good yields (70-87%) and enantioselectivities (58-72%). (C) 2016 Elsevier Ltd. All rights reserved.