One-pot synthesis of N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives

Tanyeli C. , Akhmedov I., Yazicioglu E.

TETRAHEDRON LETTERS, vol.45, no.52, pp.9627-9629, 2004 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 52
  • Publication Date: 2004
  • Doi Number: 10.1016/j.tetlet.2004.10.145
  • Title of Journal : TETRAHEDRON LETTERS
  • Page Numbers: pp.9627-9629
  • Keywords: 4,5,6,7-tetrahydroindoles, enamines, EFFICIENT, INDOLE, RING, INHIBITORS, REDUCTION, PYRROLE


We describe the preliminary results of one-pot syntheses of various N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives from 2-(2-bromoailyl)cyclohexanone and the corresponding primary amines in good yields. Aliphatic amines were directly converted to tetrahydroindoles, whereas aromatic amines needed an extra base treatment step to complete the transformation. (C) 2004 Elsevier Ltd. All rights reserved.