Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres

AYDIN O., AYDIN B., TEZCANER A., KESKİN D.

JOURNAL OF APPLIED POLYMER SCIENCE, cilt.132, sa.14, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 132 Sayı: 14
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1002/app.41768
  • Dergi Adı: JOURNAL OF APPLIED POLYMER SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: biodegradable, drug delivery systems, kinetics, properties and characterization, theory and modeling, DRUG-RELEASE, CONTROLLED DELIVERY, BIODEGRADABLE POLYMERS, SUSTAINED-RELEASE, POLY(EPSILON-CAPROLACTONE), MICROPARTICLES, ENTRAPMENT, MORPHOLOGY, PROFILES, SULFATE
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

This study aimed to develop drug delivery system of doxycycline-loaded polycaprolactone (PCL) microspheres. The investigated microsphere formulation can be considered for local application in bone infections and degenerative joint diseases, which generally require long-term treatments via systemic drugs. PCL-14 kDa and 65 kDa were used in microsphere preparation. Before release, the microspheres were characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray photoelectron spectroscopy. The mean particle size of microspheres was in the range of 74-122 mu m and their drug loadings ranged between 10 and 30%. In vitro release profiles were described using the Higuchi and the Korsmeyer-Peppas equations. Diffusion model was applied to experimental data for estimating diffusion coefficients of microspheres; calculated as between 4.5 x 10(-10) and 9.5 x 10(-10) cm(2)/s. Although long-term release from microspheres of PCL-14 kDa obeyed diffusion model, PCL-65 kDa microspheres showed this tendency only for some period. Modeling studies showed that the drug release mechanism was mainly dependent on loading and molecular weight differences. Release behavior of PCL-65 kDa microspheres, however, might be better represented by derivation of a different equation to model for the total release period. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41768