Small molecule detection by lateral flow strips via aptamer-gated silica nanoprobes

Ozalp V. C., Cam D., Hernandez F. J., Hernandez L. I., Schafer T., ÖKTEM H. A.

ANALYST, cilt.141, sa.8, ss.2595-2599, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 141 Sayı: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1039/c6an00273k
  • Dergi Adı: ANALYST
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2595-2599
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

A fast, sensitive and ratiometric biosensor strategy for small molecule detection was developed through nanopore actuation. The new platform engineers together, a highly selective molecular recognition element, aptamers, and a novel signal amplification mechanism, gated nanopores. As a proof of concept, aptamer gated silica nanoparticles have been successfully used as a sensing platform for the detection of ATP concentrations at a wide linear range from 100 mu M up to 2 mM.