In this paper, design and conduct of a partially asynchronous course on Total Quality Management are explained. Students enrolled in various engineering and other programs in a university can take the course. Also people from other institutions and industry are allowed to register for the course on a special status. In the design and conduct of the course, total quality principles are used. Planning for the future, clear objectives, participation, motivation, teamwork, leadership, problem solving, continuous improvement, empowered students, and learning assessment are given special emphasis. Major stakeholders are identified as students, graduates, instructors of the course, potential employers of the students, and the university management. Their expectations from the graduates are taken into account while designing the course. Difficulties due to the asynchronous nature of the course conduct are studied, and tried to be minimized by the design. In conducting the course, a student team is formed to improve the quality of the course as a project. The instructor works with the team in collecting data each week to assess the performance, and facilitating the team's course improvement. One semester's conduct of the course is evaluated, and the results are discussed.