Role of ABCB1 and ABCC1 Gene Induction on Survival in Locally Advanced Breast Cancer

Atalay C., DEMİRKAZIK A., GÜNDÜZ U.

JOURNAL OF CHEMOTHERAPY, cilt.20, sa.6, ss.734-739, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1179/joc.2008.20.6.734
  • Dergi Adı: JOURNAL OF CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.734-739
  • Anahtar Kelimeler: Breast cancer, ABCB1, ABCC1, survival, MULTIDRUG-RESISTANCE, P-GLYCOPROTEIN, DRUG-RESISTANCE, EXPRESSION, CHEMOTHERAPY, PROTEIN, CARCINOMA, THERAPY
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Drug resistance to chemotherapy in patients with locally advanced breast cancer results in a decrease in treatment efficacy and in patient survival. This study aimed to evaluate the impact of ABCB1 and ABCC1 gene induction during chemotherapy on disease-free and overall survival of breast cancer patients.