DNA Walker-Regulated Cancer Cell Growth Inhibition


Li F., Cha T., Pan J., Ozcelikkale A. , Han B., Choi J. H.

CHEMBIOCHEM, vol.17, no.12, pp.1138-1141, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 12
  • Publication Date: 2016
  • Doi Number: 10.1002/cbic.201600052
  • Title of Journal : CHEMBIOCHEM
  • Page Numbers: pp.1138-1141
  • Keywords: anticancer, DNA walker, DNAzyme, growth inhibition, oligonucleotides, CARBON NANOTUBES, MESSENGER-RNA, DRUG-RELEASE, ENZYME, NUCLEOLIN, APTAMERS, DELIVERY, DEVICES, SYSTEMS, MOTORS

Abstract

We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.