CHEMBIOCHEM, vol.17, no.12, pp.1138-1141, 2016 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
anticancer, DNA walker, DNAzyme, growth inhibition, oligonucleotides, CARBON NANOTUBES, MESSENGER-RNA, DRUG-RELEASE, ENZYME, NUCLEOLIN, APTAMERS, DELIVERY, DEVICES, SYSTEMS, MOTORS
Middle East Technical University Affiliated:
We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.