Phospholipid Complexation of General Anesthetics in Fluid Bilayers

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Turkyilmaz S., Mitomo H., Chen W., Regen S. L.

LANGMUIR, vol.26, no.8, pp.5309-5311, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 8
  • Publication Date: 2010
  • Doi Number: 10.1021/la100712y
  • Journal Name: LANGMUIR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5309-5311
  • Middle East Technical University Affiliated: No

Abstract

A nearest-neighbor recogntion analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a funamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC Forms 1:1 complexes with CHCl3 in both membranes in the fluid bilayer state.