Research Information System
Exploration of Medicine, vol.3, pp.1-21, 2022 (Scopus)
Abstract
Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of
bioavailability and molecular concentrations. The specific formula is then tested via in vitro and in vivo
cytotoxicity tests.
Methods: Considering the higher affinity for the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), quercetin, quercetin 3-sambubioside-3’-glucoside, luteolin,
apigenin-7-4’alloside, kaempferol-7-O-glucoside, epicatechin-epigallocatechin-3-O-gallate, and
hesperetin were selected to investigate the effects of a new combination of the formula.
Specific chemical analyses, such as high-performance liquid chromatography (HPLC), liquid
chromatography–mass spectrometry (LC–MS), quadrupole time of flight mass spectrometry (QTÖF–
MS) analysis and ultraviolet–visible (UV–VIS) spectrophotometry, were performed for molecular
qualification and quantification.
Results: In silico molecular docking analyses have shown that flavonoids can bind strongly to the spike
protein and main protease of the SARS-CoV-2 virus. Flavonoids also have anti-inflammatory and immune-
modulating activity by inhibiting cytokines. Although flavonoids may be a treatment alternative for
coronavirus disease 2019 (CÖVID-19), an effective flavonoid compound has yet to be developed. The main
problem here is that the absorption rate of flavonoids is very low (2-10%) in the intestines, and these
compounds are metabolized rapidly. In contrast, according to recent literature, a conjugated flavonoid
mixture is better absorbed in the small intestine, and its toxic effects.