In vivo half life of nanoencapsulated L-asparaginase


Baran E., Ozer N., Hasirci V.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, cilt.13, sa.12, ss.1113-1121, 2002 (SCI-Expanded) identifier identifier identifier

Özet

In the present study, antileukemic enzyme L-asparaginase (ASNase) was encapsulated into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules in order to decrease the immunogenicity and toxicity of the enzyme and to increase its in vivo half life in mice.