Mismatch between obesogenic intrauterine environment and low-fat postnatal diet may confer offspring metabolic advantage

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Kislal S., Jin W., Maesner C., Edlow A. G.

OBESITY SCIENCE & PRACTICE, vol.7, no.4, pp.450-461, 2021 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1002/osp4.501
  • Journal Name: OBESITY SCIENCE & PRACTICE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.450-461
  • Keywords: fetal programming, glucose tolerance, insulin resistance, maternal obesity
  • Middle East Technical University Affiliated: Yes

Abstract

Objective: Mismatch between a depleted intrauterine environment and a substrate-rich postnatal environment confers an increased risk of offspring obesity and metabolic syndrome. Maternal diet-induced obesity (MATOB) is associated with the same outcomes. These experiments tested the hypothesis that a mismatch between a nutrient-rich intrauterine environment and a low-fat postnatal environment would ameliorate offspring metabolic morbidity.