Asymmetric Synthesis of Trifluoromethyl Substituted Spiro[Indoline‐3,4′‐Pyrano[2,3‐c]Pyrazole] Derivatives with Organocatalysts
CHEMISTRYSELECT, cilt.9, ss.1-10, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9
- Basım Tarihi: 2024
- Doi Numarası: 10.1002/slct.202304275
- Dergi Adı: CHEMISTRYSELECT
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
- Sayfa Sayıları: ss.1-10
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
Spirocyclic compounds have always attracted attention due to
their presence as a structural core in a wide variety of natural
and bioactive molecules and to exhibit pharmaceutical properties. An asymmetric synthesis of spiro[indoline-3,4’-pyrano[2,3-
c]pyrazoles] via Michael addition of trifluoromethyl substituted
pyrazolone to isatylidene ethyl cyanoacetate derivatives was
conducted with excellent enantioselectivities up to 99% and up
to 97% isolated yield at room temperature with using 2 mol%
of bifunctional quinine derived squaramide organocatalysts.