Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme

Yalcin S., GÜNDÜZ U.

NANOMEDICINE JOURNAL, cilt.8, sa.2, ss.98-105, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.22038/nmj.2021.08.002
  • Dergi Adı: NANOMEDICINE JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.98-105
  • Anahtar Kelimeler: Anticancer effect, Breast Cancer, Etoposide, Molecular docking, PHB coated magnetic nanoparticles, siRNA, CANCER-THERAPY, DELIVERY, TUMOR, NANOCARRIERS, RELEASE, OPTIMIZATION, CYTOTOXICITY, FORMULATIONS, ACCURACY, MICELLES
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and MCF-7/1000 Etoposide resistance cells. For this purpose, PHB covered iron oxide-based magnetic nanoparticles (PHB-MNPs) were prepared by coprecipitation. We used magnetic nanoparticles because they include highly targeted to tumors in vivo cancer therapy.