Antimicrobial aptamers for detection and inhibition of microbial pathogen growth

Ozalp V. C., Bilecen K., Kavruk M., Oktem H. A.

FUTURE MICROBIOLOGY, cilt.8, sa.3, ss.387-401, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 8 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2217/fmb.12.149
  • Dergi Adı: FUTURE MICROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.387-401
  • Anahtar Kelimeler: antibiotics, antimicrobial agents, aptamers, biosensors, hygiene monitoring, multidrug resistance, pathogens, riboswitches, IMMUNODEFICIENCY-VIRUS TYPE-1, VIRAL NUCLEOPROTEIN BINDING, IN-VITRO SELECTION, DNA APTAMERS, RNA APTAMERS, SALMONELLA-TYPHIMURIUM, REVERSE-TRANSCRIPTASE, SYSTEMATIC EVOLUTION, SSDNA APTAMERS, EMERGING CLASS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Discovery of alternative sources of antimicrobial agents are essential in the ongoing battle against microbial pathogens. Legislative and scientific challenges considerably hinder the discovery and use of new antimicrobial drugs, and new approaches are in urgent demand. On the other hand, rapid, specific and sensitive detection of airborne pathogens is becoming increasingly critical for public health. In this respect affinity oligonucleotides, aptamers, provide unique opportunities for the development of nanotechnological solutions for such medical applications. In recent years, aptamers specifically recognizing microbial cells and viruses showed great potential in a range of analytical and therapeutic applications. This article describes the significant advances in the development of aptamers targeting specific pathogens. Therapeutic application of aptamers as neutralizing agents demonstrates great potential as a future source of antimicrobial agent.