Drug resistant breast cancer cells overexpress ETS1 gene

Kars M. D., Iseri O. D., GÜNDÜZ U.

BIOMEDICINE & PHARMACOTHERAPY, cilt.64, sa.7, ss.458-462, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64 Sayı: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.biopha.2010.01.008
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.458-462
  • Anahtar Kelimeler: ETS1, MCF-7, MDR1, Matrix metalloproteinases, Microarray analysis, CHRONIC LYMPHOCYTIC-LEUKEMIA, TRANSCRIPTION FACTOR, MULTIDRUG-RESISTANCE, ANTICANCER AGENTS, P53 GENE, EXPRESSION, MUTATIONS, TP53, LINES, ANGIOGENESIS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Purpose. - Multidrug resistance (MDR) is resistance to wide range of structurally unrelated anticancer agents. MDR is a serious limitation to the effective chemotherapy. Involvement of ETS1 overexpression in upregulation of MDR1 gene expression is implicated. In the present study the aim was to assess the involvement of ETS1 and the genes, which encode the proteins interacting with ETS1 in drug resistant MCF-7 breast cancer cells.