The Black Sea is a unique sea basin, rich in biodiversity, geological and cultural heritage, which is subject to combined effects of natural and human-induced stressors. The Black Sea Strategic Research and Innovation Agenda (SRIA) coordinates stakeholders from academia, funding agencies, industry, policy and society to address the specific challenges of this marine basin and promote Blue Growth and economic prosperity in the region. The EU-funded DOORS project will implement the SRIA in close cooperation with stakeholders and other projects in the region. It will harmonise research, deliver the infrastructure required to understand the Black Sea ecosystems, develop a structure to support Blue Growth and the early development of start-ups, and provide evidence to shape policy in line with the Black Sea SRIA.