Akademik Veri Yönetim Sistemi
DOĞAN Ö. (Yürütücü)
TÜBİTAK Projesi, 1001 - Bilimsel ve Teknolojik Araştırma Projelerini Destekleme Programı, 2018 - 2020
Pyrrolidine skeleton is found in the structure of many natural compounds. Almost all of the pyrrolidine derivatives show some biological activities and some of them are used as drugs. For this reason it is important to synthesize new pyrrolidine derivatives especially in their asymmetric forms. One of the important reaction used for the synthesis of these compounds is 1,3-dipolar cycloaddition reaction of azomethine ylides with dipolarophiles. This is one of the most efficient and atom economical reaction, because two “C-C” bonds and up to four chirality centers can be created in a single step. Our group have synthesized ferrocenyl substituted aziridinyl methanol (shortly FAM) chiral ligands and used with a metal as chiral catalyst for the enantioselective synthesis of organic compounds including pyrrolidines. In this project these chiral catalysts will be used for the enantioselective synthesis of heteroaryl substituted pyrrolidine derivatives for the first time in the literature. New derivatives of FAM chiral catalysts will also be synthesized and their catalytic performance will be tested for the first time in this project as well. Although literature has reasonable number of good examples to chiral catalyst for the eanantioselective synthesis of pyrrolidines, the number of chiral catalysts reported for the synthesis of heteroaryl substituted pyrrolidines is very limited. Therefore it is important to develop new chiral catalysts for the asymmetric synthesis of heteroaryl substituted pyrrolidines.