Blood supply network design

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Tezin Türü: Doktora

Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Mühendislik Fakültesi, Endüstri Mühendisliği Bölümü, Türkiye

Tezin Onay Tarihi: 2016

Öğrenci: MUSTAFA MERT YEGÜL

Danışman: FATMA SEDEF MERAL

Özet:

In our study, we consider a joint location-inventory-routing problem with multiple location layers for a distinctive and regionalized blood supply network design. We formulate the problem as a mixed-integer nonlinear programming model and present an optimal solution method for the problem. However, solving medium and large-sized problem instances for the optimal solution turns out to be impractical. Therefore, we also develop several heuristic methods based on decomposition and simulated annealing techniques. We conduct extensive computational studies on numerous test problems and evaluate the performance of the solution methods proposed. Our results show that simulated annealing heuristic clearly outperforms other solution methods.