Blood supply network design


Thesis Type: Doctorate

Institution Of The Thesis: Orta Doğu Teknik Üniversitesi, Faculty of Engineering, Department of Industrial Engineering, Turkey

Approval Date: 2016

Student: MUSTAFA MERT YEGÜL

Supervisor: FATMA SEDEF MERAL

Abstract:

In our study, we consider a joint location-inventory-routing problem with multiple location layers for a distinctive and regionalized blood supply network design. We formulate the problem as a mixed-integer nonlinear programming model and present an optimal solution method for the problem. However, solving medium and large-sized problem instances for the optimal solution turns out to be impractical. Therefore, we also develop several heuristic methods based on decomposition and simulated annealing techniques. We conduct extensive computational studies on numerous test problems and evaluate the performance of the solution methods proposed. Our results show that simulated annealing heuristic clearly outperforms other solution methods.