Synthesis and characterization of ultra-small gadolinium oxide nanoparticles

Thesis Type: Postgraduate

Institution Of The Thesis: Orta Doğu Teknik Üniversitesi, Faculty of Arts and Sciences, Department of Chemistry, Turkey

Approval Date: 2017




Ultra-small gadolinium oxide nanoparticles are used as contrast agents for molecular and cellular magnetic resonance imaging (MRI) procedure. They are also important for drug targeting magnetic separation and gene therapy applications due to their paramagnetic properties. Gadolinium oxide nanoparticles have been known to have the highest gadolinium density of all paramagnetic gadolinium contrast agents since they generate strong positive contrast enhancement. There are many techniques that have been introduced to synthesize gadolinium oxide nanoparticles. In this study, we optimized a simple polyol-free method for preparation of ultra-small nanosize (<4 nm) Gd2O3 nanoparticles. They are successfully synthesized in aqueous medium in an ultra-small nanosize 1.5-2.5 nm range which is the optimum size range needed for maximal contrast enhancement in MRI. After synthesizing gadolinium oxide nanoparticles, to analyze and characterize them, X-ray spectroscopy, scanning electron microscope (SEM), transmission electron microscope (TEM) and ultraviolet-visible spectrophotometry (UV-VIS) were used. These nanoscale particles has been shown to have promising properties to function as a contrast agent for MRI imaging.