Design and characterization of 5-l autoclavable batch-culture bioreactor /

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Thesis Type: Postgraduate

Institution Of The Thesis: Middle East Technical University, Turkey

Approval Date: 2014

Thesis Language: English

Student: Şeyma Ünsal Beyge

Co-Supervisor: EMREN NALBANT ESENTÜRK, ÇAĞDAŞ DEVRİM SON

Abstract:

Bioreactors are systems that use a biological agent to perform a chemical reaction. Developments on the field of biotechnology made production of even previously known non-renewable petro-chemical products to be produced by microorganism by use of bioreactors possible. Also developments on tissue engineering made it possible to produce organs by using bioreactors. Therefore, bioreactors become integral parts of future economy and technology. In this study prototyping of a small scale bioreactor was performed. Heat transfer system which can cause temperature change of minimum 0.2 °C/seconds was produced. Also an agitation system that can operate up to 1500 rpm without any contamination risk was developed and produced. For effective foam/level control a miniature multi-probe foam/level sensor with 2 mm sensitivity and 50 mm working range was developed and tested.