Preparation and characterization of magnetite nanoparticles by thermal decomposition method for their potential use in tumor imaging

Thesis Type: Postgraduate

Institution Of The Thesis: Orta Doğu Teknik Üniversitesi, Faculty of Arts and Sciences, Department of Chemistry, Turkey

Approval Date: 2010




In biomedical applications, magnetic nanoparticles have been used as they offer attractive possibilities. First, they have controllable sizes ranging from a few nanometers up to tens of nanometers and second, the nanoparticles are magnetic and magnetic fields can penetrate into human tissue which means that they can be manipulated by an external magnetic field gradient. In this study, Fe₃O₄ nanoparticles are synthesized by thermal decomposition method for their potential use in cancer diagnosis. Techniques like TEM, XRD, and FTIR were performed to control the properties of the synthesized particles whether they are suitable for certain applications. In thermal decomposition method, two different iron precursors were employed to obtain magnetite nanoparticles. In the usage of Fe(acac)₃, approximate particle sizes obtained by this method lie between 3-6 nm. When, Fe(CO)₅ was used as the iron precursor, average particles size of 6 nm were obtained. Rhenium carbonyl complex was prepared by reductive carboxylation utilizing gaseous carbon monoxide as a source of carbonyl and amino borane, BH₃NH₃ as the reducing agent. HPLC-ICP-MS was used for measuring complex formation. 95% conversion of perrhenate into the complex was seen. In this part, rhenium is selected as a surrogate of radioactive ⁹⁹mTc. ¹⁸⁸Re and ¹⁸⁶Re can also be used in radioactive therapy.