Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Türkiye
Tezin Onay Tarihi: 2013
Tezin Dili: İngilizce
Öğrenci: Ezgi Demircan
Eş Danışman: CİHANGİR TANYELİ, AYHAN SITKI DEMİR
Özet:The proline–calix[4]arene thiourea host–guest complex catalyzed intermolecular aldol reaction of aromatic aldehydes with cyclohexanone is developed. The anti-configured products were obtained in good yields and high enantioselectivities. The reaction is proposed to work via modified Houk–List model, where the carboxylate part of the proline constitutes a supramolecular system with the thiourea. The outcome of the study indicates the influence of the calix[4]arene thiourea on the reactivity and selectivity in a non-polar reaction medium, even in the presence of water at moderate temperatures.